6 edition of Regulation of Myocardial Contractile Function and Metabolism found in the catalog.
January 31, 1989
Written in English
|The Physical Object|
|Number of Pages||388|
The regulation of mammalian myocardial carbohydrate metabolism is complex in that it is linked to arterial substrate and hormone levels, coronary flow, inotropic state and the nutritional status of the tissue. Optimal cardiac function under normal and pathological conditions is dependent upon glycolysis and pyruvate by: Impaired mitochondrial biogenesis and function associated with derangement of cardiac metabolism play vital roles in the pathogenesis of diabetic cardiomyopathy. Therefore metabolic regulation targeting mitochondrial dysfunction may show therapeutic potential for treating diabetic by:
Myocardial remodeling and fibrosis: extracellular matrix reorganization and collagen metabolism; cytoskeleton. Cardiac myocyte contractile function: sarcomeric proteins; calcium regulation and signaling; calcium-force relationship; arrhythmia-related causes of remodeling and heart failure. We report that, in addition to regulating a plethora of myocardial genes, this transcriptionally based mechanism potentially regulates myocardial contractile function and metabolism. Importantly, we provide evidence that the cardiomyocyte circadian clock influences both heart rate and the responsiveness of the heart to increased by:
impact of cardiomyocyte-specific bmal1 deletion on myocardial gene expression, metabolism, and contractile function Circadian clocks are cell autonomous, transcriptionally-based, molecular mechanisms that confer the selective advantage of anticipation, enabling cells/organs to respond to environmental factors in a temporally appropriate manner. The metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the present study was to determine the metabolic profiles in myocardial and skeletal muscle in HF and exercise training using MRS, and thus to identify targets for clinical MRS in Author: Mingshu Shi, Øyvind Ellingsen, Tone Frost Bathen, Morten A. Høydal, Tomas Stølen, Morteza Esmaeili.
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Importantly, elevated myocardial GRK2 levels enhanced negative cardiac glucose metabolism after ischemic injury and these effects precede GRK2-mediated ventricular contractile dysfunction This was the first report to link adrenergic control of contractility and metabolism; GRK2 appears to be this nodal link and the metabolic dysfunction that occurs first after cardiac Author: Meryl C.
Woodall, Michele Ciccarelli, Benjamin P. Woodall, Walter J. Koch. To gain insite into the mechanisms of myocardial regulation as it relates to the interaction of mechanical and metabolic function and perfusion, intact animal models were instrumented for routine Metabolic regulation of in vivo myocardial contractile function: multiparameter analysis | Cited by: 5.
Circadian clock regulation of myocardial metabolism. While it is evident from the discussion above that carbohydrate, lipid, and protein metabolism exhibit time-of-day-dependent rhythms in the heart questions still remain as to how this regulation occurs and what the advantage of such rhythms might by: myocardial contractile function may be related to alterations in the regulation of energy metabolism in hypertrophic hearts.
In the present simulation study, we provide a novel systematic perspective to investigate myocardial contractile and energy metabolic properties of FHC. By incorporating electrophysiologyCited by: 2.
The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP.
The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change. Regulation of cell size and contractile function by AKT in cardiomyocytes. Latronico MV(1), Costinean S, Lavitrano ML, Peschle C, Condorelli G.
Author information: (1)Laboratory of Molecular Cardiology, San Raffaele Biomedical Science Park of Rome, by: Myocardial Substrate Metabolism in the Normal and Failing Heart. Physiol Rev myocardial metabolism and cardiac function often occur late in the development of HF.
Thus one must use caution The regulation of myocardial metabolism is linked to arterial carbon substrate concentration, hormone concen-Cited by: Administration of L-carnitine reduces ischemic myocardial injury in a number of experimental model systems and may improve the clinical outcomes of patients with acute myocardial infarction.
The efficacy of carnitine in this setting is probably not attributable to an increase in fatty acid oxidation, which can be detrimental to myocardial recovery during by: There are two major types of cardiac muscle cells: myocardial contractile cells and myocardial conducting cells.
The myocardial contractile cells constitute the bulk (99 percent) of the cells in the atria and ventricles. Contractile cells conduct impulses and are responsible for contractions that pump blood through the body.
In the present study, we sought to test the hypothesis that the level of cardiac βARK1 activity regulates myocardial contractile functionin vivo.
To test these hypotheses, we used a strategy that utilized mouse genetics to create varying levels of βARK1 activity in the heart, coupled with a physiological assessment of contractile function in.
In this study, we used an integrated simulation that links electrophysiology, contractile activity and energy metabolism of the myocardium to investigate alterations in myocardial contractile function and energy metabolism regulation as a result of increased Ca 2+ sensitivity in CTnI by: 2.
Major abnormalities in myocardial carbohydrate and lipid metabolism occur as a result of insulin deficiency. The Role of Ca in the Regulation of Muscle Activity 1 other sections not shown.
Other editions - View all. The Myocardial Cell: Structure, Function, and Modification by Cardiac Drugs effect intracellular ionic ions isometric length-tension curve level of membrane load maximum mechanism membrane potential metabolism myocardial myofibrils.
W.C. Stanley. Time for primary review 28 days. The regulation of mammalian myocardial carbohydrate metabolism is complex in that it is linked to arterial substrate and hormone levels, coronary. Heart failure (HF) is characterized by molecular and cellular defects which jointly contribute to decreased cardiac pump function.
During the development of the initial cardiac damage which leads to HF, adaptive responses activate physiological countermeasures to overcome depressed cardiac function and to maintain blood supply to vital organs in demand of by: Multiple extracardiac stimuli, such as workload and circulating nutrients (e.g., fatty acids), known to influence myocardial metabolism and contractile function exhibit marked circadian rhythms.
The aim of the present study was to investigate whether the rat heart exhibits circadian rhythms in its responsiveness to changes in workload and/or Cited by: Dramatic changes in cardiac metabolism and contractile function, also occur during myocardial reperfusion as a consequence of the generation of oxygen free radicals, loss of cation homeostasis, depletion of energy stores, and changes in subcellular activities.
Myocardial metabolism. Muhammad Adnan Amin Cardiology, THI Outline Regulation of metabolic pathways in the heart Carbohydrate metabolism Fatty acid metabolism Ketone body metabolism Interregulation of fatty acid and carbohydrate oxidation Effects of substrate selection on contractile function and efficiency.
Regulation of Metabolic Pathways in the Heart. Gain a foundational understanding of cardiovascular physiology and how the cardiovascular system functions in health and vascular Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal function and disease with pathophysiology content throughout the : The regulation of cell function is generally achieved through participation of a wide variety of hormones and different signal transduction mechanisms for the activation/deactivation of some specific metabolic processes.
In this regard cyclic AMP and calcium seem to play a crucial role. Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms addresses the vascular smooth muscle function by describing plasma lipoprotein structure, synthesis, and transport in relation to the concepts of altered vascular smooth muscle lipid metabolism leading to the genesis of atherosclerotic Edition: 1.A.
Special Lecture.- 1. Molecular Biology and Cardiac Function, Past, Present and Future.- B. Electrical Events and Ions.- 2. Regulation of Calcium Slow Channels and Potassium Channels of Cardiac Muscle by Cyclic Nucleotides and Metabolism.- 3. Potassium Channels Identified with Single Channel Recordings and Their Role in Cardiac Excitation.- 4.
A plentiful and continuous production of energy is critical for the maintenance of cardiac function. The signalling pathways that ensure an adequate supply of energy to the heart are complex.
We now know that the control of myocardial fuel metabolism becomes deranged in the diseased by: